S. Yi

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Lymphoid origin of a lineage of intrinsically activated plasmacytoid dendritic cell in mice and humans

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

Evolved and plastic gene expression in adaptation to a novel niche

The paper investigates evolved and plastic gene expression differences in adaptation to a novel niche using peacock flies, finding ecotype-specific gene expression changes and an inversion linked to differential expression.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

Co-transcriptional translation amplifies mRNA noise in Escherichia coli

This study shows co-transcriptional translation in E. coli increases mRNA noise by amplifying transcriptional variability and altering bursting kinetics.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

Two distinct binding modes provide the RNA binding protein RbFox with extraordinary sequence specificity

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

The Combination of Morphology and Surface Chemistry Defines the Biological Identity of Nanocarriers in Human Blood

The paper shows that both the surface chemistry and morphology of nanocarriers influence their protein corona composition and immune interactions in human blood.

Denisovan ancestry and population history of early East Asians

The paper analyzes the genome of a 34,000-year-old hominin from Mongolia, showing Denisovan ancestry and gene flow from West Eurasians in early East Asians.

Health behaviors among male and female university students in Cambodia: a cross-sectional survey

This study surveys health behaviors of Cambodian university students, finding low substance use and sexual risk behaviors but concerning levels of physical inactivity and poor diet.

Accelerated evolution of oligodendrocytes in human brain

The paper compares gene expression evolution in neurons and oligodendrocytes across humans, chimpanzees, and rhesus macaques, finding accelerated evolution in oligodendrocytes linked to schizophrenia.