E. A. Scott

Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion

The paper designs a symmetry-broken tetrahedral protein cage by modifying subunits to display a single copy of an outward-facing domain.

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

Targeted Delivery of Chloroquine to Plasmacytoid Dendritic Cells Enhances Inhibition of the Type I Interferon Response

This study shows that delivering chloroquine via nanocarriers specifically to plasmacytoid dendritic cells reduces type I interferon production in SLE models.

Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy

This paper develops FLT4-targeted nanocarriers for glaucoma therapy, showing improved IOP reduction and targeted delivery to Schlemms canal cells.

Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability

This paper shows subcutaneous rapamycin delivery via nanocarriers changes its immunosuppressive mechanism, improving islet graft survival in a transplant model.

The Combination of Morphology and Surface Chemistry Defines the Biological Identity of Nanocarriers in Human Blood

The paper shows that both the surface chemistry and morphology of nanocarriers influence their protein corona composition and immune interactions in human blood.

Co-administration of macropinocytosis inhibitory nanoparticles (MiNP) for enhanced nanoparticle circulation time and target tissue accumulation following subcutaneous injection

This paper shows that co-injecting macropinocytosis inhibitory nanoparticles (MiNP) with targeted nanoparticles improves their circulation time and tissue accumulation after subcutaneous injection.

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

This study shows that nanocarrier surface chemistry can stabilize or denature adsorbed albumin, affecting macrophage clearance through SR-A1 receptor recognition.