Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms
F. He, A. B. A. Laranjeira, t. kong, A. Liu, K. Bark, N. M. Lasky, D. A. C. Fisher, M. J. Cox, M. Fulbright, L. A. Heck, L. Yu, S. M. Sykes, A. DAlessandro, J. Di Paola, S. Oh
This study identifies metabolic alterations in MPN platelets, showing that alpha-ketoglutarate supplementation reduces hyperreactivity and inflammation.
Journal of Clinical Investigation · Feb 1, 2024Peer-reviewedCancer Biology