A. Liu

Micron-resolution fiber mapping in histology independent of sample preparation

This paper introduces ComSLI, a method to map fiber networks in histology without sample preparation, showing its application across tissues and diseases.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Membrane vesicles can contribute to cellulose degradation by Teredinibacter turnerae, a cultivable intracellular endosymbiont of shipworms

This study shows that Teredinibacter turnerae produces membrane vesicles containing cellulolytic enzymes, which may aid in lignocellulose degradation and host-symbiont interactions.

The freeze-avoiding mountain pine beetle (Dendroctonus ponderosae) survives prolonged exposure to stressful cold by mitigating ionoregulatory collapse

This study examines how mountain pine beetle larvae maintain ion balance during cold exposure and finds that ionoregulatory collapse limits their cold tolerance.

Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

The paper shows how Drosophila larvae influence the lifestyle and pathogenicity of Serratia marcescens at the single-cell level through transcriptomic and metabolic changes.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

Structural insights into agonist binding and activation of succinate receptor 1

This study presents cryo-EM structures of SUCNR1-Gi complexes bound to succinate and epoxysuccinate, revealing key residues and structural changes involved in agonist binding and activation.

Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

This study identifies metabolic alterations in MPN platelets, showing that alpha-ketoglutarate supplementation reduces hyperreactivity and inflammation.

The Porcine Skin Microbiome Exhibits Broad Fungal Antagonism

This study characterizes the porcine skin microbiome, identifies antifungal bacterial isolates, and discovers novel fungal and bacterial species with potential for antifungal applications.

Structural basis for constitutive activation and CXCL1 recognition of human herpesvirus 8-encoded G protein-coupled receptor KSHV-GPCR

This study determines the cryo-EM structures of KSHV-GPCR in complex with Gi and CXCL1, revealing structural mechanisms of constitutive activation and ligand binding.

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in active state

This paper presents a cryo-EM structure of CXCL12-bound CXCR4 in an active state, revealing key interactions that stabilize the ligand-receptor complex.

Aerosolized α1 adrenoreceptor antagonism does not affect experimentally induced lung fibrosis in animal models

This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.

Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

Endoplasmic reticulum exit sites are segregated for secretion based on cargo size

The paper shows that ERES segregate based on cargo size, with bulky cargoes accumulating less at stalled ERES compared to small molecules.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

The paper identifies dual regulation of SLC25A39 by AFG3L2 and iron, showing how this controls mitochondrial glutathione homeostasis in neurons.

Targeted Protein Relocalization via Protein Transport Coupling

This paper demonstrates targeted protein relocalization using shuttle proteins and small molecules to redistribute disease-associated proteins and alleviate cellular stress and neurodegeneration.

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

This study determines the cryo-EM structure of the EROS-NOX2-p22phox complex, revealing how EROS binds to NOX2 and regulates its activation.

Cell Fate Programming by Transcription Factors and Epigenetic Machinery in Stomatal Development

This study investigates how transcription factors and epigenetic machinery regulate stomatal development in Arabidopsis by analyzing scRNA-seq and ChIP-seq data, revealing chromatin remodeling mechanisms.

Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin

This study investigates how phosphorylation at S579 and S600 affects Drp1 GTPase activity, showing that S579 phosphorylation reduces actin and cardiolipin stimulation while S600 phosphorylation inhibits these effects.

Endocytosis gated by emergent properties of membrane-clathrin interactions

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

Long-chain fatty acyl-coenzyme A activates the mitochondrial fission factors MiD49 and MiD51 by inducing their oligomerization

This study shows that long-chain fatty acyl-CoA activates mitochondrial fission proteins MiD49 and MiD51 by inducing their oligomerization, which enhances DRP1 GTPase activity and promotes mitochondrial fission.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Cryo-EM structures of the human G-protein coupled receptor 1 (GPR1) - Gi protein complexes bound to the full-length chemerin and to its C-terminal nonapeptide

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

Nematostella vectensis exemplifies the exceptional expansion and diversity of opsins in the eyeless Hexacorallia

This study identifies 29 opsins in the sea anemone Nematostella vectensis, showing lineage-specific duplications and diverse expression patterns, suggesting novel sensory functions in eyeless cnidarians.

Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter

The paper genetically manipulates Saccharibacteria from the CPR to study their role in epibiotic growth and develops bioinformatic resources for their analysis.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome (LTCS) patients

This study identifies persistent metabolic, proteomic, and immunologic imbalances in long-term COVID-19 syndrome (LTCS) patients compared to healthy controls and acute COVID-19 patients.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

In-Vitro Efficacy of Targeted FODMAP Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment

This study evaluates the efficacy of FODZYME(R), a fructan hydrolase enzyme supplement, in breaking down inulin in a simulated gastrointestinal environment, reducing gas production while preserving short-chain fatty acid production.