Cell BiologybioRxiv
Hepatitis B virus x (HBx) protein increases cellular OCT3/4 and MYC and facilitates cellular reprogramming (of fibroblasts to iPSC)
M. G. Sanal, S. Gupta, R. Saha…·S. K. Sarin
This study shows HBx enhances reprogramming efficiency of fibroblasts to iPSC by increasing OCT3/4 and MYC levels, and can substitute MYC in the Yamanakas factor cocktail.
DOI 10.1089/cell.2023.0055