Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
A. Garcia-Gomez, T. Li, J. Rodriguez-Ubreva, L. Ciudad, F. Catala-Moll, M. Martin, L. San-Segundo, X. Morales, C. Ortiz de Solorzano, J. Oyarzabal, E. San Jose-Eneriz, X. Agirre, F. Prosper, M. Garayoa, E. Ballestar
This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.
bioRxiv · Sep 12, 2019Cancer Biology