BiochemistrybioRxiv
Substrate dynamics contribute to enzymatic specificity in human and bacterial methionine adenosyltransferases
M. H. GADE, L. L. Tan, A. M. Damry…·P. Laurino
This study investigates how substrate conformational dynamics influence enzymatic specificity in human and bacterial methionine adenosyltransferases, revealing differences in catalytic promiscuity and identifying a new metabolite in cancer cells.
DOI 10.1021/jacsau.1c00464