Author

M. Iskar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Zapatka· 4 shared P. Lichter· 3 shared F. Czernilofsky· 2 shared P.-M. Bruch· 2 shared S. Dietrich· 2 shared T. Roider· 2 shared A. Cosma· 1 shared A. Ernst· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

M. Zapatka

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Author profile →

4 papers

Recent·Most cited

High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target

L. L. Cid, J. K. Leong, I. F. Botana, Y. Paul, M. Wierz, A. Floerchinger, S. Gonder, G. Pagano, M. Chazotte, K. Bestak, C. Schifflers, M. Iskar, T. Roider, F. Czernilofsky, P.-M. Bruch, , M. Seiffert

The paper defines CLL T cell subtypes and identifies Galectin-9 as a novel immunotherapy target through single-cell and multi-omics analyses.

bioRxiv · Dec 15, 2022 · PreprintCancer Biology

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

S. A. Herbst, M. Vesterlund, A. J. Helmboldt, R. Jafari, I. Siavelis, M. Stahl, E. Schitter, N. Liebers, B. Brinkmann, F. Czernilofsky, T. Roider, P.-M. Bruch, M. Iskar, A. Kittai, Y. Huang, , Hu

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

bioRxiv · Mar 1, 2022Cancer Biology

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

U. Khalid, M. Simovic, M. Iskar, J. K. L. Wong, R. Kumar, M. Jugold, M. Sill, M. Bolkestein, T. Kolb, M. Hergt, F. Devens, J. Ecker, M. Kool, T. Milde, F. Westermann, , A. Ernst

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

bioRxiv · Apr 22, 2021Cancer Biology

The landscape of viral associations in human cancers

M. Zapatka, I. Borozan, D. S. Brewer, M. Iskar, A. Grundhoff, M. Alawi, N. Desai, H. Sueltmann, H. Moch, PCAWG Pathogens Working Group, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network, C. S. Cooper, R. Eils, V. Ferretti, P. Lichter

The paper systematically investigates viral associations in human cancers using whole-genome and transcriptome data from 2,656 donors, revealing prevalence of known tumor-associated viruses and their genomic impacts.

bioRxiv · Sep 9, 2019Cancer Biology