Author

A. Grundhoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 8 Approach:experimental assay· 7 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3

Frequent Co-Authors

T. Günther· 4 shared M. Aepfelbacher· 2 shared N. Fischer· 2 shared A. Carstens· 1 shared A. Sugimoto· 1 shared A. Werner· 1 shared A.-S. Schroeder· 1 shared C. Edler· 1 shared

Activity by Year

2019-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

T. Günther

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Yersinia remodels epigenetic histone modifications in human macrophages

I. Bekere, J. Huang, M. Schnapp, M. Rudolph, L. Berneking, K. Ruckdeschel, A. Grundhoff, T. Günther, N. Fischer, M. Aepfelbacher

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

bioRxiv · Sep 7, 2021Microbiology

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

S. Jost, O. Lucar, T. Yoder, K. Kroll, S. Sugawara, S. Smith, R. Jones, G. Tweet, A. Werner, P. J. Tomezsko, H. L. Dugan, J. Ghofrani, M. Altfeld, A. Grundhoff, M. Muller-Trutwin, , R. K. Reeves

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

bioRxiv · Nov 9, 2020 · PreprintImmunology

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

S. Pfefferle, T. Guenther, V. Puelles, F. Heinrich, D. Noerz, M. Czech-Sioli, A. Carstens, S. Krasemann, M. Wong, L. Oestereich, T. Magnus, L. Allweiss, C. Edler, A.-S. Schroeder, M. Dandri, , N. Fischer

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

bioRxiv · Oct 10, 2020 · PreprintMicrobiology

The landscape of viral associations in human cancers

M. Zapatka, I. Borozan, D. S. Brewer, M. Iskar, A. Grundhoff, M. Alawi, N. Desai, H. Sueltmann, H. Moch, PCAWG Pathogens Working Group, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network, C. S. Cooper, R. Eils, V. Ferretti, P. Lichter

The paper systematically investigates viral associations in human cancers using whole-genome and transcriptome data from 2,656 donors, revealing prevalence of known tumor-associated viruses and their genomic impacts.

bioRxiv · Sep 9, 2019Cancer Biology

Oncogenic herpesvirus engages the endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

S. Gramolelli, E. Elbasani, V. Nurminen, K. Tuohinto, T. Günther, R. E. Kallinen, S. P. Kaijalainen, R. Diaz, A. Grundhoff, C. Haglund, J. M. Ziegelbauer, M. Bower, M. Francois, P. M. Ojala

This study shows that SOX18 and PROX1, endothelial transcription factors, regulate KSHV lytic replication and virus production in lymphatic endothelial cells.

bioRxiv · Aug 27, 2019Microbiology

The first days in the life of naïve human B-lymphocytes infected with Epstein-Barr virus

D. Pich, P. Mrozek-Gorska, M. Bouvet, A. Sugimoto, E. Akidil, A. Grundhoff, S. Hamperl, P. Ling, W. Hammerschmidt

This study identifies EBNA2 as essential for early EBV infection of naive B-cells, showing it drives activation, proliferation, and prevents cell death, while other latent genes have minimal or no effect during the pre-latent phase.

bioRxiv · Jun 11, 2019Microbiology

Human cytomegalovirus nuclear capsid motility is non-directed and independent of nuclear actin bundles

F. Flomm, E. M. Borst, T. Günther, R. Reimer, L. de Vries, C. Schneider, A. Grundhoff, K. Grünewald, M. Messerle, J. Bosse

This study investigates whether HCMV-induced nuclear actin bundles mediate capsid transport, finding no evidence of directed motility or active transport along nuclear F-actin.

bioRxiv · May 24, 2019 · PreprintMicrobiology

A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment

T. Günther, J. Fröhlich, L. Burkhardt, C. Herrde, S. Ohno, H. Adler, A. Grundhoff

This study compares the epigenetic features of KSHV and MHV-68, showing that KSHV rapidly recruits polycomb repressive complexes through specific cis-acting sequence features, unlike MHV-68.

bioRxiv · May 15, 2019Microbiology