Author

F. Devens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Ernst· 3 shared S. Pfister· 3 shared A. Korshunov· 2 shared M. Jugold· 2 shared M. Kool· 2 shared M. Sill· 2 shared M. Simovic· 2 shared M. Zapatka· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Ernst

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Author profile →

3 papers

Recent·Most cited

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

I. Kats, H. S. Schreiber, M. Simovic, P. Sant, J.-P. Mallm, A. Li, P. Velmurugan, S. Weil, F. Devens, M. Sill, M. Jugold, M. Moustafa, A. Abdollahi, F. Winkler, A. Korshunov, , A. Ernst

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

bioRxiv · Mar 3, 2023 · PreprintCancer Biology

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

U. Khalid, M. Simovic, M. Iskar, J. K. L. Wong, R. Kumar, M. Jugold, M. Sill, M. Bolkestein, T. Kolb, M. Hergt, F. Devens, J. Ecker, M. Kool, T. Milde, F. Westermann, , A. Ernst

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

bioRxiv · Apr 22, 2021Cancer Biology

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

M. Ratnaparkhe, J. Wong, P.-C. Wei, M. Hlevnjak, T. Kolb, D. Haag, Y. Paul, F. Devens, P. Northcott, D. T. Jones, M. Kool, A. Jauch, A. Pastorczak, W. Mlynarski, A. Korshunov, , A. Ernst

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.

bioRxiv · May 4, 2018Cancer Biology