Author

M. Simovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Ernst· 4 shared M. Sill· 3 shared O. Stegle· 3 shared A. Korshunov· 2 shared F. Devens· 2 shared M. Jugold· 2 shared M. Zapatka· 2 shared R. Kumar· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. Ernst

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4 papers

Recent·Most cited

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

I. Kats, H. S. Schreiber, M. Simovic, P. Sant, J.-P. Mallm, A. Li, P. Velmurugan, S. Weil, F. Devens, M. Sill, M. Jugold, M. Moustafa, A. Abdollahi, F. Winkler, A. Korshunov, , A. Ernst

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

bioRxiv · Mar 3, 2023 · PreprintCancer Biology

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures

T. Rausch, R. Snajder, A. Leger, M. Simovic, O. Stegle, E. Birney, M. J. Bonder, A. Ernst, J. O. Korbel

This study uses long-read sequencing to analyze medulloblastoma genomes and epigenomes, revealing complex structural variants and methylation patterns.

bioRxiv · Feb 20, 2022Cancer Biology

Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability

R. G. Parra, M. J. Przybilla, M. Simovic, H. Susak, M. Ratnaparkhe, J. K. Wong, V. Koerber, P. Mallm, M. Sill, T. Kolb, R. Kumar, N. Casiraghi, D. R. Ghasemi, K. K. Maass, K. W. Pajtler, , A. Ernst

This study analyzes single-cell multi-omics data from medulloblastoma to explore genomic and transcriptomic impacts of chromothripsis and its subclonal variation.

bioRxiv · Jun 25, 2021 · PreprintCancer Biology

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

U. Khalid, M. Simovic, M. Iskar, J. K. L. Wong, R. Kumar, M. Jugold, M. Sill, M. Bolkestein, T. Kolb, M. Hergt, F. Devens, J. Ecker, M. Kool, T. Milde, F. Westermann, , A. Ernst

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

bioRxiv · Apr 22, 2021Cancer Biology