Author

M. J. Lucas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

B. K. Keitz· 2 shared D. W. Taylor· 2 shared E. J. Verbeke· 2 shared H. S. Pan· 2 shared J. M. Zupancic· 2 shared L. J. Webb· 2 shared P. M. Tessier· 2 shared B. Zhang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. K. Keitz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

J. M. Zupancic, M. D. Smith, H. Trzeciakiewicz, M. E. Skinner, S. P. Ferris, E. K. Makowski, M. J. Lucas, N. McArthur, R. S. Kane, H. L. Paulson, P. M. Tessier

This study selects conformational nanobodies specific for aggregated tau using flow cytometry, showing their utility in detecting tau aggregates in mouse and human samples.

bioRxiv · May 13, 2023 · PreprintBioengineering

Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs

G. Pornnoppadol, L. G. Bond, M. J. Lucas, J. M. Zupancic, Y.-H. Kuo, B. Zhang, C. F. Greineder, P. M. Tessier

This paper develops bispecific antibody shuttles targeting CD98hc for efficient and long-lived brain delivery of IgGs, showing improved retention and specificity compared to TfR-1 shuttles.

bioRxiv · Apr 29, 2023Bioengineering

Cross-seeding Controls Aβ Fibril Populations and Resulting Function

H. S. Pan, M. J. Lucas, E. J. Verbeke, G. M. Partipilo, E. C. Helfman, L. Kann, B. K. Keitz, D. W. Taylor, L. J. Webb

This study investigates how cross-seeding of amyloid-beta peptides affects fibril structure and toxicity, showing that mutant seeds influence both structure and cytotoxicity in WT peptides.

bioRxiv · Oct 14, 2021Biochemistry

Functionalized Mesoporous Silicas Direct Structural Polymorphism of Amyloid-β Fibrils

M. J. Lucas, H. S. Pan, E. J. Verbeke, L. J. Webb, D. W. Taylor, B. K. Keitz

This paper shows that functionalized mesoporous silicas control the structural polymorphism of Aβ1-40 fibrils, with hydrophobic silicas producing fibrils more similar to those in AD patient samples.

bioRxiv · Jan 13, 2020Biochemistry