M. D. Smith

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

This study selects conformational nanobodies specific for aggregated tau using flow cytometry, showing their utility in detecting tau aggregates in mouse and human samples.

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.

Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program

This paper evaluates a mouse model of Dravet syndrome for antiseizure drug screening, finding that it is highly refractory to common ASDs but responsive to specific treatments like clobazam and valproic acid.

Inhibitor binding influences the protonation states of histidines in SARS-CoV-2 main protease

This study uses molecular dynamics simulations to investigate how inhibitor binding affects the protonation states of histidines in SARS-CoV-2 main protease, showing their impact on structural stability and inhibitor binding.

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia

The paper uses machine learning to predict adenylate-forming enzyme function and substrate specificity, revealing a β-lactone biosynthesis pathway in Nocardia.