Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca2+-mediated p38 MAP kinase activation
N. M. Blythe, V. Stylianidis, M. J. Ludlow, H. T. Gilbert, E. L. Evans, K. Cuthbertson, R. Foster, J. Swift, J. Li, M. J. Drinkhill, F. A. van Nieuwenhoven, K. E. Porter, D. J. Beech, N. A. Turner
This study shows that activating Piezo1 channels in cardiac fibroblasts reduces myofibroblast differentiation and increases IL-6 secretion through Ca2+-dependent p38 MAP kinase activation.
bioRxiv · Apr 10, 2019Cell Biology