Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
M. R. Spaeth, K. J. R. Hoyer-Allo, M. Johnsen, M. Hoehne, C. Lucas, S. Brodesser, J.-W. Lackmann, K. Kiefer, F. C. Koehler, P. Schiller, T. Kubacki, F. Grundmann, T. Benzing, B. Schermer, V. Burst, R.-U. Mueller
This study identifies KYNU-dependent de novo NAD+ biosynthesis as a mechanism by which caloric restriction protects against acute kidney injury in mice and humans.
bioRxiv · Aug 20, 2021Physiology