T. Benzing

Correlation of calcium multiphoton with ultrastructural STED imaging of the slit diaphragm in the same glomerulus.

The paper correlates calcium multiphoton imaging with STED imaging of the slit diaphragm in the same glomerulus to study kidney disease mechanisms.

The FSGS disease gene product and nuclear pore protein NUP205 regulates nuclear localization and activity of the transcriptional regulators YAP and TAZ in podocytes

This paper identifies NUP205 as a regulator of YAP/TAZ nuclear import and activity in podocytes, linking NUP dysfunction to FSGS pathogenesis.

Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes on capillaries

This study shows that podocyte processes align along the capillary axis to balance mechanical strain during kidney filtration.

Three-dimensional Super-resolved Imaging of Paraffin-embedded Kidney Samples

This paper develops protocols for three-dimensional STED and confocal imaging of FFPE kidney tissue, achieving similar staining and image quality as previous methods.

JADE family proteins regulate proteasome abundance and activity

This study identifies JADE proteins as regulators of proteasome abundance and activity, showing their role in modulating proteasome turnover and stability through direct interactions.

A systematic analysis of diet-induced nephroprotection reveals overlapping and conserved changes in cysteine catabolism

This study compares six dietary regimens to identify their protective effects against kidney injury and finds overlapping metabolic changes in cysteine catabolism across diets.

Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway

This study identifies KYNU-dependent de novo NAD+ biosynthesis as a mechanism by which caloric restriction protects against acute kidney injury in mice and humans.

Deep learning-based segmentation and quantification of podocyte foot process morphology

This paper develops a deep learning method to segment and quantify podocyte foot process morphology in kidney tissue, confirming morphological changes in disease states.

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levels

This study shows that Par3A and Par3B regulate RhoA levels and podocyte architecture through interactions with Synaptopodin and CD2AP in mouse and Drosophila models.