C. Lucas

Chikungunya virus infection disrupts lymph node lymphatic endothelial cell composition and function via MARCO

This study shows CHIKV infection disrupts lymph node lymphatic endothelial cell composition and function through MARCO interactions, leading to impaired antigen acquisition and increased inflammation.

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition

This study shows that SARS-CoV-2 Omicron subvariants are better at suppressing MHC-I expression than earlier variants, aiding their evasion from CD8+ T cell immunity.

Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development

This study shows that sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development, with male-specific macrophage responses driving tumour regression.

Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation

This study shows that loss of SENP2 causes adrenal cortex zonal defects and glucocorticoid deficiency by disrupting transdifferentiation and signaling pathways.

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

This paper describes a synthetic bispecific antibody that neutralizes SARS-CoV-2 Delta and Omicron variants with picomolar affinity.

No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway

This study identifies KYNU-dependent de novo NAD+ biosynthesis as a mechanism by which caloric restriction protects against acute kidney injury in mice and humans.

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Discovery of NOvel CIP2A VAriant (NOCIVA) and its clinical relevance in myeloid leukemias

The paper discovers a novel CIP2A splicing variant, NOCIVA, which is overexpressed in myeloid leukemias and correlates with poor clinical outcomes.