M. K. Graham

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.