Author

R. Chikarmane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

S. Yegnasubramanian· 4 shared A. M. De Marzo· 3 shared J. Liu· 3 shared T. L. DeWeese· 3 shared A. Gupta· 2 shared A. M. Vaghasia· 2 shared A. Skaist· 2 shared J. Meyers· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

S. Yegnasubramanian

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Author profile →

4 papers

Recent·Most cited

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

J. B. Coulter, M. Haffner, Y. Zhang, H. Zhou, M.-T. N. Pham, J. Chen, R. Chikarmane, A. Mishra, M. S. Mehl, S. Kazibwe, K. Choi, A. Archey, S. Valluri, S. E. Lupold, D. Song, , S. Yegnasubramanian

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

M. K. Graham, R. Wang, R. Chikarmane, B. Wodu, A. Vaghasia, A. Gupta, Q. Zheng, J. Hicks, P. Sysa-Shah, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, Y. Zhang, , S. Yegnasubramanian

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

bioRxiv · Sep 7, 2023Cancer Biology

RepairSwitch: simultaneous functional assessment of homologous recombination and end joining DNA repair pathways in living cells

R. C. Steinberg, J. Liu, A. M. Vaghasia, H. Giovinazzo, M.-T. N. Pham, D. Tselenchuk, R. Chikarmane, M. C. Haffner, W. G. Nelson, S. Yegnasubramanian

The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.

bioRxiv · Jan 17, 2023 · PreprintCell Biology

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

M. K. Graham, R. Chikarmane, R. Wang, A. M. Vaghasia, A. Gupta, Q. Zheng, B. P. Wodu, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, S. J. Wheelan, B. W. Simons, C. Bieberich, , S. Yegnasubramanian

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

bioRxiv · Jan 31, 2022Cell Biology