The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2
A. Chatterjee, B. Gallent, M. Katiki, C. Qian, M. R. Harter, M. R. Freeman, R. Murali
This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.
bioRxiv · Jun 13, 2023Biophysics