Author

B. Gallent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Qian· 2 shared M. R. Freeman· 2 shared R. Murali· 2 shared A. Chatterjee· 1 shared B. S. Knudsen· 1 shared B. Zhang· 1 shared C. Morrissey· 1 shared D. Di Vizio· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

C. Qian

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

C. Qian, Q. Yang, M. Rotinen, R. Huang, h. Kim, B. Gallent, Y. Yan, R. M. Cadaneanu, B. Zhang, S. Kaochar, S. J. Freedland, E. M. Posadas, L. Ellis, D. Di Vizio, C. Morrissey, , M. R. Freeman

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

bioRxiv · Sep 28, 2023 · PreprintCancer Biology

The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2

A. Chatterjee, B. Gallent, M. Katiki, C. Qian, M. R. Harter, M. R. Freeman, R. Murali

This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.

bioRxiv · Jun 13, 2023Biophysics