C. Qian

Exposure assessment suggests some cytotoxic Bacillus cereus group genotypes can grow over 3 logs in HTST milk throughout the shelf life at temperature abuse conditions

This study develops an exposure assessment model to predict B. cereus group growth in HTST milk under temperature abuse conditions, showing some genotypes can reach 105 CFU/mL by day 35 of storage.

Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2

This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.

Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles

The paper introduces particle-based phasor-FLIM-FRET to quantify protein-protein interactions in single viral particles, showing it can accurately measure FRET efficiency with low signal intensities.

Genome-scale requirements for dynein-based trafficking revealed by a high-content arrayed CRISPR screen

The paper uses a CRISPR screen to identify genes critical for dynein-based trafficking, revealing novel regulators and functional relationships in microtubule transport.

m6A modifications regulate intestinal immunity and rotavirus infection

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

Active anaerobic methane oxidation and sulfur disproportionation in the deep terrestrial subsurface

The paper demonstrates active anaerobic methane oxidation and sulfur disproportionation in deep terrestrial subsurface environments using metaproteogenomics and isotopic analysis.

Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

This study shows that multi-session delivery of rTMS paired with sensory stimulation induces long-term plasticity in the rat primary somatosensory cortex, while single sessions or sensory stimulation alone do not.

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

Clinical Characteristics and Risk of Second Primary Lung Cancer After Cervix Cancer: A Population-Based Study

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

Fully Automated Peptide Mapping Protocol for Multi-Attribute Method by Liquid Chromatography-Tandem Mass Spectroscopy with a High-Throughput Robotic Liquid Handling System

This paper describes an automated peptide mapping protocol using a robotic liquid handling system to improve reproducibility and reduce hands-on time compared to manual methods.