Cancer BiologyCancer CellPeer-reviewed
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
M. Kilian, R. Sheinin, C. L. Tan…·M. Platten
This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.
DOI 10.1016/j.ccell.2022.12.007