Author

M. Killer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Loew· 3 shared E. Pardon· 2 shared G. Finocchio· 2 shared J. Steyaert· 2 shared A.-S. Humm· 1 shared D. I. Svergun· 1 shared F. Dupeux· 1 shared H. Mertens· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

C. Loew

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Author profile →

3 papers

Recent·Most cited

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

V. Kotov, M. Killer, K. E. J. Jungnickel, J. Lei, G. Finocchio, J. Steinke, K. Bartels, J. Strauss, F. Dupeux, A.-S. Humm, I. Cornaciu, J. A. Marquez, E. Pardon, J. Steyaert, C. Loew

The paper investigates the substrate recognition mechanism of the bacterial POT DtpB using structural and biochemical analyses, revealing that compact hydrophobic peptides are optimal binders.

bioRxiv · Feb 14, 2023Biophysics

Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C

M. Killer, G. Finocchio, H. Mertens, D. I. Svergun, E. Pardon, J. Steyaert, C. Loew

This study determines the cryo-EM structure of DtpC, an atypical proton-coupled peptide transporter, revealing structural insights into its ligand selectivity.

bioRxiv · Apr 12, 2022Biophysics

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes

M. Killer, J. Wald, J. Pieprzyk, T. C. Marlovits, C. Loew

The paper presents cryo-EM structures of human PepT1 and PepT2 to elucidate their transport mechanisms and provide insights for drug design.

bioRxiv · Jul 7, 2021Biophysics