J. Lei

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.

Involvement of TRPV4 in temperature-dependent perspiration in mice

This study shows TRPV4 is involved in temperature-dependent perspiration in mice through interactions with ANO1, and its expression is higher in normohidrotic AIGA patients.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice

This study shows that influenza A virus suppresses progesterone in pregnant mice, leading to adverse maternal and fetal outcomes, which can be mitigated by progestin treatment.

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

Migratory herbivorous waterfowl track multiple resource waves during spring migration

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

The paper investigates the substrate recognition mechanism of the bacterial POT DtpB using structural and biochemical analyses, revealing that compact hydrophobic peptides are optimal binders.

Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

Mechanism of treatment-free remission in patients with chronic myeloid leukemia revealed by a computational model of CML evolution

The paper develops a computational model to study the mechanisms of treatment-free remission in CML patients, revealing the role of the neoplastic microenvironment and leukemia stem cell dynamics.

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Structure insights of the human peroxisomal ABC transporter ALDP

The paper reports the cryo-EM structure of human ALDP, revealing its conformation and potential lipid-binding site, which aids in understanding disease-causing mutations.

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the Long QT Syndrome

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

Effect of the BMPR-II-SMAD3/MRTF complex on proliferation and migration of ASMCs and the mechanism in asthma.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

Activated Expression of Master Regulator MYB31 and of Capsaicinoid Biosynthesis Genes Results in Capsaicinoid Biosynthesis and Accumulation in the Pericarp of the Extremely Pungent Capsicum chinense

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

Molecular architecture of the SARS-CoV-2 virus

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells

This study introduces single-cell entropy (scEntropy) to quantify reprogramming and differentiation dynamics in iPSCs using scRNA-seq data, showing increases during differentiation and decreases during reprogramming.

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein

The paper uses computational simulations to study the binding dynamics between human ACE2 and the SARS-CoV-2 spike protein's RBD, revealing critical residues and binding modes.

Structural basis for pore blockade of the human cardiac sodium channel Nav1.5 by tetrodotoxin and quinidine

The paper presents cryo-EM structures of Nav1.5 bound to tetrodotoxin and quinidine, revealing mechanisms of pore blockade and disease mutation mapping.