Author

M. Knott

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Argentiero· 1 shared A. G. Solimando· 1 shared A. Kerscher· 1 shared A. Marchetto· 1 shared A. Marquardt· 1 shared A. Shlien· 1 shared A. Y. Rudensky· 1 shared Alexander BüchneriD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

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10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. Argentiero

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4 papers

Recent·Most cited

Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progression

Zuzanna Kolodynska, Kimberley M. Hanssen, Florian H. Geyer, M. Knott, Karim Aljakouch, Alina Ritter, Alexandra Delipetrou, Jeroen Krijgsveld, Erick Mitchell-Velasquez, Irfan Ahmed Asangani, Rainer D. Will, Martina Müller‐Nurasyid, Konstantin Strauch, Alexander Büchner, Florencia Cidre‐Aranaz, Thomas G. P. Grünewald

This study identifies PTPRK as a gene modulated by TMPRSS2::ERG fusion and a regulatory SNP, showing its role in prostate cancer progression and potential as a biomarker.

bioRxiv · Aug 5, 2025 · PreprintCancer Biology

A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life

B. Akagbosu, Z. Tayyebi, G. Shibu, Y. A. Paucar Iza, D. Deep, Y. Franco Parisotto, H. A. Pasolli, V. Thevin, R. Elmentaite, M. Knott, S. Hemmers, L. Jahn, C. Friedrich, J. Verter, Z. Wang, , C. C. Brown

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

bioRxiv · Feb 26, 2022Immunology

Visual Clustering of Transcriptomic Data from Primary and Metastatic Tumors - Dependencies and Novel Pitfalls

A. Marquardt, P. Kollmannsberger, M. Krebs, A. Argentiero, M. Knott, A. G. Solimando, A. Kerscher

The paper evaluates how data transformation and dimension reduction methods affect clustering of transcriptomic data from metastases and primary tumors, finding no strong link between tumor site and cluster formation.

bioRxiv · Dec 3, 2021Cancer Biology

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer

J. Musa, F. Cidre-Aranaz, M.-M. Aynaud, M. F. Orth, O. Mirabeau, M. Varon, S. Grossetete, D. Surdez, S. Ohmura, J. S. Gerke, A. Marchetto, M. Dallmayer, M. C. Baldauf, M. Gartlgruber, F. Westermann, , T. G. P. Grunewald

This study shows how a dominant oncogene and regulatory germline variants together influence tumor growth, survival, and drug response in Ewing sarcoma.

bioRxiv · Dec 27, 2018Cancer Biology