A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life
B. Akagbosu, Z. Tayyebi, G. Shibu, Y. A. Paucar Iza, D. Deep, Y. Franco Parisotto, H. A. Pasolli, V. Thevin, R. Elmentaite, M. Knott, S. Hemmers, L. Jahn, C. Friedrich, J. Verter, Z. Wang, , C. C. Brown
This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.
bioRxiv · Feb 26, 2022Immunology