Author

M. L. Arnold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Driscoll· 2 shared A. J. Smart· 1 shared A. Singh· 1 shared B. D. Grant· 1 shared C. Kumsta· 1 shared C. M. Lange· 1 shared D. H. Hall· 1 shared E. H. Choy· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

M. Driscoll

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2 papers

Recent·Most cited

Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain

Y. Yang, M. L. Arnold, E. H. Choy, C. M. Lange, K. Poon, M. Broussalian, L.-H. Sun, T. M. Moreno, A. Singh, M. Driscoll, C. Kumsta, M. Hansen

The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.

bioRxiv · Dec 12, 2022 · PreprintCell Biology

Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed C. elegans Neurons and Influence Large Vesicle Extrusions as Exophers

M. L. Arnold, J. F. Cooper, R. Androwski, S. Ardeshna, I. Melentijevic, A. J. Smart, R. J. Guasp, K. C. Nguyen, G. Bai, D. H. Hall, B. D. Grant, M. Driscoll

This study shows that intermediate filaments in C. elegans neurons form aggresome-like structures under proteostress and influence exopher production for aggregate removal.

bioRxiv · Aug 3, 2022 · PreprintCell Biology