Cell BiologybioRxivPreprint
Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain
Y. Yang, M. L. Arnold, E. H. Choy…·M. Hansen
The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.
DOI 10.1101/2022.12.12.520171