M. Hansen

BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors

This study investigates how glucocorticoids and TRKB signaling interact to modulate neuronal plasticity, finding that glucocorticoids promote TRKB dimerization and interact with TRKB to influence its activity and behavioral effects.

Epigenetic reprogramming shapes the cellular landscape of schwannoma

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Non-target Analysis of Wastewater Treatment Plant Effluents: Chemical Fingerprinting as a Monitoring Tool.

This paper develops a non-targeted screening method to analyze xenobiotic compounds in wastewater effluents, revealing significant differences in compound diversity across three treatment facilities.

Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain

The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.

Environmental gradients reveal stress hubs predating plant terrestrialization

The paper uses RNAseq and photophysiological data from Mesotaenium under environmental stress to identify stress response hubs in algae, suggesting ancient molecular programs predating plant terrestrialization.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

Late-in-life treadmill-training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.

This study shows that treadmill training in old mice improves autophagy, protein aggregate clearance, and heart function.

Comparison of Mucosal and Intramuscular Immunization against SARS-CoV-2 with Replication-Defective and Replicating Single-cycle Adenovirus Vaccines

This study compares mucosal and intramuscular immunization with replication-defective and replicating single-cycle adenovirus vaccines against SARS-CoV-2, showing that replicating vaccines generate stronger antibody responses.

Temporal instability of lake charr phenotypes: synchronicity of growth rates and morphology linked to environmental variables?

The paper examines phenotypic variation in lake charr ecotypes over time, finding a synchronized shift in morphology and growth rates linked to environmental changes like cloud cover.

Among-individual diet variation within a lake trout ecotype: lack of stability of niche use.

The paper examines diet variation among lake trout within an ecotype, finding that individual trophic specialization occurs despite lack of genetic or morphological differentiation.

Dietary vs non-dietary fatty acid profiles of lake trout ecotypes from Lake Superior and Great Bear Lake: Are fish really what they eat?

The paper examines non-dietary fatty acid profiles in lake trout ecotypes to assess their ability to distinguish intraspecific diversity across lakes and ecotypes.

Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, \"Silenusvirus\".

The paper isolates and characterizes novel phages infecting Lactobacillus plantarum, proposes a new genus Silenusvirus, and supports classification into the Siphoviridae family.

Sporaefaciens musculi gen. nov., sp. nov., a novel bacterium isolated from the caecum of an obese mouse

The paper isolates and characterizes a novel bacterium from an obese mouse's caecum, proposing a new genus and species based on genomic and phenotypic data.

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.