The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer
M. L. Beshiri, B. J. Capaldo, R. Lake, A. T. Ku, D. Burner, C. M. Tice, C. Tran, J. Kostas, A. N. Alilin, J. Yin, S. Agarwal, S. A. Morris, F. H. Karzai, T. L. Lotan, W. L. Dahut, , K. Kelly
This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.
bioRxiv · Mar 24, 2022 · PreprintCancer Biology