J. Yin

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

YamOmics compiles and organizes multi-omics data from 41 yam species, providing genomic, transcriptomic, and plastomic data along with variant and expression information for yam research and breeding.

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

This study shows that targeting both AMPK and mTOR can inhibit prostate cancer metastasis by blocking the metabolic switch required for tumor growth in new environments.

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

This study shows melanin protects melanoma cells from ferroptosis, enhancing metastasis, and suggests targeting melanin and ferroptosis could improve treatment of metastatic melanoma.

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

This study identifies leafhoppers as vectors for SoSGV, a virus associated with soybean stay-green syndrome, and shows they can transmit the virus to legume plants.

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

This study examines how host genetics and environmental factors shape root microbiota in switchgrass across its native range, finding heritable variation and local microbial recruitment.

The paper uses cell-type-specific transcriptomics to show how WCS417 affects root cell types, revealing roles for root hairs in immunity and endodermal barriers in beneficial association.

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

The paper develops a zebrafish xenograft model of metastatic uveal melanoma and identifies ferroptosis as a druggable vulnerability in tumors with BAP1 loss.

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This study shows vitamin C enhances plasma cell differentiation in mouse and human B cells by epigenetic remodeling via TET enzymes and STAT3-dependent mechanisms.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study analyzes ACE2 gene conservation and expression patterns in 11 animals, finding high conservation but species-specific RNA and protein expression.