Author

K. Kelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Immunology· 4 Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Organism:human· 8 Research Focus:cell type annotation· 7 Research Focus:differential expression· 5 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

S. Agarwal· 5 shared A. N. Alilin· 4 shared A. G. Sowalsky· 2 shared A. T. Ku· 2 shared B. Capaldo· 2 shared B. J. Capaldo· 2 shared E. Corey· 2 shared J. Yin· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

S. Agarwal

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

F. Ahmad, M. White, K. Yamamoto, D. R. Crooks, S. Agarwal, Y. Yang, B. Capaldo, S. Raj, A. N. Alilin, A. Ton, S. Adler, J. Seidel, C. Olkowski, M. K. Cherukuri, P. L. Choyke, , J. R. Brender

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

bioRxiv · Nov 15, 2023Cancer Biology

Addressing the dNTP bottleneck restricting prime editing activity

K. Ponnienselvan, P. Liu, T. Nyalile, S. Oikemus, A. T. Joynt, K. Kelly, D. Guo, Z. Chen, J. M. Lee, C. A. Schiffer, C. P. Emerson, N. D. Lawson, J. K. Watts, E. J. Sontheimer, J. Luban, S. A. Wolfe

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

bioRxiv · Oct 21, 2023Biochemistry

Eelgrass (Zostera spp.) associated phytomyxids are host-specific congeneric parasites and predominant eukaryotes in the eelgrass rhizosphere on a global scale

V. Kolatkova, M. Mooney, K. Kelly, E. Hineva, R. M. R. Gawryluk, J. Elliott

The paper identifies phytomyxid parasites as host-specific, predominant eukaryotes in eelgrass rhizospheres globally, challenging their previous perception as rare.

bioRxiv · Mar 5, 2023 · PreprintMicrobiology

Mycobacterium tuberculosis-specific CD4 T cells expressing transcription factors associate with bacterial control in granulomas

N. L. Grant, K. Kelly, P. Maiello, H. Abbott, S. L. O'Connor, P. L. Lin, C. A. Scanga, J. L. Flynn

The paper identifies Mtb-specific CD4 T cells in granulomas and shows that transcription factors T-bet and RORγT correlate with bacterial control.

bioRxiv · Nov 30, 2022 · PreprintImmunology

Vitamin D and the ability to produce 1,25(OH)2D are critical for protection from viral infection of the lungs.

J. Arora, D. R. Patel, M. J. Nicol, C. J. Field, K. H. Restori, J. Wang, N. E. Froelich, B. Katkere, J. A. Terwilliger, V. Weaver, E. Luley, K. Kelly, G. S. Kirimanjeswara, T. C. Sutton, M. T.-A. Cantorna

This study shows that vitamin D deficiency worsens lung inflammation during H1N1 and SARS-CoV-2 infections, while sufficient vitamin D reduces inflammation, though not viral replication.

bioRxiv · Jun 29, 2022Immunology

Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer

S. Agarwal, L. Fang, K. McGowen, J. Yin, J. Bowman, A. N. Alilin, A. T. Ku, E. Corey, M. Roudier, L. True, R. Dumpit, I. Coleman, J. Lee, P. S. Nelson, B. J. Capaldo, , K. Kelly

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer

M. L. Beshiri, B. J. Capaldo, R. Lake, A. T. Ku, D. Burner, C. M. Tice, C. Tran, J. Kostas, A. N. Alilin, J. Yin, S. Agarwal, S. A. Morris, F. H. Karzai, T. L. Lotan, W. L. Dahut, , K. Kelly

This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.

bioRxiv · Mar 24, 2022 · PreprintCancer Biology

Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking

S. S. Schmieder, R. Tatituri, M. Anderson, K. Kelly, W. I. Lencer

The paper identifies a structural motif in ceramide acyl chains that determines glycosphingolipid sorting via endocytic pathways and shows its dependence on cholesterol.

bioRxiv · Apr 26, 2021Cell Biology

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

M. G. P. van der Wijst, S. E. Vazquez, G. C. Hartoularos, P. Bastard, T. Grant, R. Bueno, D. S. Lee, J. R. Greenland, Y. Sun, R. Perez, A. Ogorodnikov, A. Ward, S. A. Mann, K. L. Lynch, C. Yun, , C. R. Langelier

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

bioRxiv · Mar 9, 2021 · PreprintImmunology

Subgenomic RNAs as molecular indicators of asymptomatic SARS-CoV-2 infection

C. H. Wong, C. Y. Ngan, R. L. Goldfeder, J. Idol, C. Kuhlberg, R. Maurya, K. Kelly, G. Omerza, N. Renzette, F. D. Abreu, L. Li, F. A. Browne, E. T. Liu, C.-L. Wei

The paper examines subgenomic RNA (sgRNA) expression and structural variations in symptomatic and asymptomatic SARS-CoV-2 infections to correlate with disease severity.

bioRxiv · Feb 6, 2021 · PreprintMicrobiology

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

S. C. Baca, D. Y. Takeda, J.-H. Seo, J. Hwang, S. Y. Ku, R. Arafeh, T. Arnoff, S. Agarwal, C. Bell, E. O'Connor, X. Qiu, S. Abu Alaiwi, R. I. Corona, M. A. S. Fonseca, C. Giambartolomei, , M. L. Freedman

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

bioRxiv · Oct 23, 2020Cancer Biology

Distinct SARS-CoV-2 Antibody Reactivity Patterns in Coronavirus Convalescent Plasma Revealed by a Coronavirus Antigen Microarray

R. Ramiro de Assis, A. Jain, R. Nakajima, A. Jasinskas, S. Khan, L. J. Dumont, K. Kelly, G. Simmons, M. Stone, C. Di Germanio, M. P. Busch, P. L. Felgner

This study uses a coronavirus antigen microarray to identify distinct antibody reactivity patterns in SARS-CoV-2 convalescent plasma, showing high concordance with existing assays and revealing clusters with potential implications for treatment efficacy.

bioRxiv · Sep 16, 2020Immunology

Targeting the PI3K/AKT pathway overcomes enzalutamide resistance by inhibiting induction of the glucocorticoid receptor

R. M. Adelaiye-Ogala, B. Gryder, Y. T. M. Nguyen, A. N. Alilin, A. Grayson, K. H. Jansson, M. L. Beshiri, S. Agarwal, B. Capaldo, J. A. Rodriguez-Nieves, K. Kelly, D. J. VanderWeele

This study shows that inhibiting the PI3K/AKT pathway blocks GR induction and overcomes enzalutamide resistance in prostate cancer by remodeling chromatin and enhancing AR activity.

bioRxiv · Oct 1, 2019Cancer Biology