Pharmacology & ToxicologybioRxiv
PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication
L. A. Emert-Sedlak, C. M. Tice, H. Shi…·T. E. Smithgall
This study develops PROTACs to degrade HIV-1 Nef, restoring CD4 and MHC-I expression and inhibiting HIV-1 replication in T cells and PBMCs.
DOI 10.1016/j.chembiol.2024.02.004