Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
M. Claiborne, S. Sengupta, L. Zhao, M. L. Arwood, I.-M. Sun, J. Wen, E. A. Thompson, M. Mitchell-Flack, M. Laiho, J. D. Powell
The paper identifies CAD-induced pyrimidine synthesis and ribosomal biogenesis as critical for rapid recall responses in memory CD8+ T cells.
bioRxiv · Nov 10, 2021Immunology