Author

M. Mitchell-Flack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

A. Tam· 2 shared D. M. Pardoll· 2 shared A. G. Dykema· 1 shared A. J. Munoz· 1 shared A. Lebid· 1 shared B. Zhang· 1 shared C. A. Sawosik· 1 shared C. G. Drake· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. Tam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

H. Yu, H. Nishio, J. Barbi, M. Mitchell-Flack, P. D. A. Vignali, Y. Zheng, A. Lebid, K.-Y. Chang, J. Fu, M. Higgins, C.-T. Huang, X. Zhang, Z. Li, L. Blosser, A. Tam, , D. M. Pardoll

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

bioRxiv · Jan 31, 2024Immunology

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

A. G. Dykema, J. Zhang, B. Zhang, L. S. Cheung, Z. Zeng, C. M. Cherry, T. Li, J. X. Caushi, M. Nishimoto, S. Connor, Z. Ji, A. J. Munoz, W. Hou, W. Zhan, D. Singh, , K. N. Smith

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

bioRxiv · Dec 13, 2022 · PreprintImmunology

Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge

M. Claiborne, S. Sengupta, L. Zhao, M. L. Arwood, I.-M. Sun, J. Wen, E. A. Thompson, M. Mitchell-Flack, M. Laiho, J. D. Powell

The paper identifies CAD-induced pyrimidine synthesis and ribosomal biogenesis as critical for rapid recall responses in memory CD8+ T cells.

bioRxiv · Nov 10, 2021Immunology