G. Reifenberger

This study uses CRISPRoff to introduce site-specific CpG methylation in the MGMT promoter of glioblastoma cells, showing reduced MGMT expression and increased temozolomide sensitivity.

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

This study shows EIF4EBP1 is upregulated by MYCN and linked to poor prognosis in neuroblastoma, with high expression associated with reduced survival and unfavorable histology.

The paper identifies a novel subset of supratentorial ependymomas in children characterized by recurrent PLAGL1 fusions and distinct molecular features.

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.