Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.
J. Ye, I. A. Calvo, I. Cenzano, A. Vilas-Zornoza, X. Martinez-de-Morentin, M. Lasaga, D. Alignani, B. Pavia, A. C. Vinado, P. San Martin-Uriz, J. P. Romero, D. Quilez Agreda, M. MinanaBarrios, I. Sancho-Gonzalez, G. Todisco, , D. Gomez-Cabrero
The paper develops a bioinformatic pipeline to analyze scRNA-seq data and identifies intermediate cell states and differentiation stages in the hematopoietic stem cell regulatory microenvironment, revealing conservation between mouse and human.
bioRxiv · Jul 17, 2021 · PreprintImmunology