Author

D. Alignani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Gomez-Cabrero· 4 shared F. Prosper· 4 shared A. Vilas-Zornoza· 3 shared J. Tegner· 3 shared P. San Martin-Uriz· 3 shared B. Paiva· 2 shared B. Saez· 2 shared D. Lara-Astiaso· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersImmunology

D. Gomez-Cabrero

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

I. Cenzano, M. Cocera, M. Larrayoz, L. Campos-Dopazo, S. Sanz, A. Bantan, A. Vilas, P. San-Martin, P. Aguirre-Ruiz, D. Alignani, A. Lopez, I. Sancho Gonzalez, J. Ruiz, P. Ripalda-Cemborain, M. Abengozar-Muela, , F. Prosper

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

bioRxiv · Apr 24, 2024Cancer Biology

Uncovering the regulatory landscape of early human B-cell lymphopoiesis and its implications in the pathogenesis of B-cell acute lymphoblastic leukemia

N. Planell, X. Martinez-de-Morentin, D. Mouzo, D. Lara-Astiaso, A. Vilas-Zornoza, P. San Martin-Uriz, D. Alignani, B. Paiva, A. Maillo, A. Kurowska, N. Berastegui, P. Garcia-Olloqui, A. Urdangarin, P. Noori, A. Ortega-Legarreta, , D. Gomez-Cabrero

This study characterizes the gene regulatory network of early human B-cell development and identifies regulatory elements linked to B-cell acute lymphoblastic leukemia.

bioRxiv · Jul 1, 2023 · PreprintImmunology

Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.

J. Ye, I. A. Calvo, I. Cenzano, A. Vilas-Zornoza, X. Martinez-de-Morentin, M. Lasaga, D. Alignani, B. Pavia, A. C. Vinado, P. San Martin-Uriz, J. P. Romero, D. Quilez Agreda, M. MinanaBarrios, I. Sancho-Gonzalez, G. Todisco, , D. Gomez-Cabrero

The paper develops a bioinformatic pipeline to analyze scRNA-seq data and identifies intermediate cell states and differentiation stages in the hematopoietic stem cell regulatory microenvironment, revealing conservation between mouse and human.

bioRxiv · Jul 17, 2021 · PreprintImmunology

Single-cell RNA-seq analysis reveals the crucial role of Collagen Triplex Helix Repeat Containing 1 (CTHRC1) cardiac fibroblasts for ventricular remodeling after myocardial infarction

A. Ruiz-Villalba, J. P. Romero, S. C. Hernandez, A. Vilas-Zornoza, N. Fortelny, L. Castro, P. San Martin-Uriz, E. Lorenzo-Vivas, P. Garcia-Olloqui, M. Palacios, J. J. Gavira, G. Bastarrika, S. Janssens, E. Iglesias, G. Abizanda, , F. Prosper

This study identifies a pro-fibrotic fibroblast subpopulation in mice after myocardial infarction, showing CTHRC1's role in ventricular remodeling and cardiac function.

bioRxiv · May 20, 2019Cell Biology