Author

B. Saez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:clustering· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

F. Prosper· 4 shared D. Gomez-Cabrero· 3 shared I. Cenzano· 3 shared J. Tegner· 3 shared A. Bantan· 2 shared A. Vilas-Zornoza· 2 shared B. Paiva· 2 shared D. Alignani· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

F. Prosper

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling

L. Sudupe, E. Muinos-Lopez, A. R. Lopez-Perez, A. Vilas-Zornoza, S. Sarvide, P. Ripalda-Cemborain, P. Aguirre-Ruiz, P. San Martin-Uriz, M. Larrayoz, L. Alvarez-Gigli, M. Abengozar-Muela, I. Cenzano, M. Cocera, J. Ruiz, I. Sancho Gonzalez, , F. Prosper

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

bioRxiv · Jul 3, 2024 · PreprintCancer Biology

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

T. Kooistra, B. Saez, M. Roche, A. Egea-Zorrilla, D. Li, D. Anketell, N. Nguyen, J. Villoria, J. Gillis, E. Petri, L. Vera, N. P. Smith, J. Alladina, Y. Zhang, V. Vinarsky, , A. Pardo-Saganta

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

bioRxiv · Jun 25, 2024Cell Biology

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

I. Cenzano, M. Cocera, M. Larrayoz, L. Campos-Dopazo, S. Sanz, A. Bantan, A. Vilas, P. San-Martin, P. Aguirre-Ruiz, D. Alignani, A. Lopez, I. Sancho Gonzalez, J. Ruiz, P. Ripalda-Cemborain, M. Abengozar-Muela, , F. Prosper

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

bioRxiv · Apr 24, 2024Cancer Biology

Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.

J. Ye, I. A. Calvo, I. Cenzano, A. Vilas-Zornoza, X. Martinez-de-Morentin, M. Lasaga, D. Alignani, B. Pavia, A. C. Vinado, P. San Martin-Uriz, J. P. Romero, D. Quilez Agreda, M. MinanaBarrios, I. Sancho-Gonzalez, G. Todisco, , D. Gomez-Cabrero

The paper develops a bioinformatic pipeline to analyze scRNA-seq data and identifies intermediate cell states and differentiation stages in the hematopoietic stem cell regulatory microenvironment, revealing conservation between mouse and human.

bioRxiv · Jul 17, 2021 · PreprintImmunology

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

L. Maneix, P. Iakova, S. E. Moree, J. C. K. King, D. B. Sykes, C. T. Hill, B. Saez, E. Spooner, D. S. Krause, E. Sahin, B. C. Berk, D. T. Scadden, A. Catic

This study identifies Cyclophilin A as a key regulator of protein phase separation and shows its role in mitigating haematopoietic stem cell aging.

bioRxiv · Feb 24, 2021Cell Biology