Author

M. Leake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:fluorescence / live-cell microscopy· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1

Frequent Co-Authors

A. Wollman· 3 shared A. C. Noy· 1 shared A. Harvgreaves· 1 shared A. J. McCormick· 1 shared A. J. Wilkinson· 1 shared A. J. Wollman· 1 shared A. L. Payne-Dwyer· 1 shared A. Maxwell· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

A. Wollman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The role of BST4 in the pyrenoid of Chlamydomonas reinhardtii

L. Adler, C. S. Lau, K. M. Shaikh, K. v. Maldegem, A. L. Payne-Dwyer, C. Lefoulon, P. Girr, N. Atkinson, J. Barrett, T. Z. Emrich-Mills, E. Dukic, M. R. Blatt, M. Leake, G. Peltier, C. Spetea, , C. E. Walker

The paper shows BST4 in Chlamydomonas is an ion channel involved in thylakoid lumenal pH regulation, not a tethering protein for pyrenoid tubules.

bioRxiv · Jun 15, 2023 · PreprintPlant Biology

The emergence of sequence-dependent structural motifs in stretched, torsionally constrained DNA

J. W. Shepherd, R. J. Greenall, M. I. J. Probert, A. C. Noy, M. Leake

This study shows that DNA sequence affects structural motifs under mechanical stress, with GC-rich sequences being more stable than AT-rich ones.

bioRxiv · Apr 4, 2019Biophysics

Mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells

A. Wollman, E. Hedlund, S. Shashkova, M. Leake

The paper introduces a method to map 3D genome organization in living cells using single-molecule tracking of transcription factors in budding yeast.

bioRxiv · Mar 5, 2019Biophysics

Single-molecule imaging of DNA gyrase activity in living Escherichia coli

M. Stracy, A. Wollman, E. Kaja, J. Gapinski, J.-E. Lee, V. Leek, S. McKie, L. Mitchenall, A. Maxwell, D. Sherratt, M. Leake, P. Zawadzki

This study uses single-molecule imaging to analyze DNA gyrase activity in live E. coli, showing gyrase dynamics and supercoil regulation during replication.

bioRxiv · Nov 1, 2018Biophysics

Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

A. Syeda, A. Wollman, A. Harvgreaves, J. Bruning, P. McGlynn, M. Leake

The paper uses single-molecule live cell imaging to study the dynamic interactions of the bacterial helicase Rep with the replisome and PriC, revealing two distinct mechanisms for overcoming nucleoprotein barriers during DNA replication.

bioRxiv · Sep 29, 2018Biophysics

Stoichiometry and Mobility Switching of a Morphogenetic Protein in Live Differentiating Cells

A. J. Wollman, K. Muchova, Z. Chromikova, A. J. Wilkinson, I. Barak, M. Leake

The paper uses single-molecule fluorescence microscopy to study SpoIIE dynamics in Bacillus subtilis during sporulation, revealing changes in stoichiometry and mobility that enable stage-specific functions.

bioRxiv · Jun 27, 2018 · PreprintMicrobiology