Author

M. Stracy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. Sherratt· 3 shared A. J. Baldwin· 1 shared A. kapanidis· 1 shared A. Maxwell· 1 shared A. N. Kapanidis· 1 shared A. Turner· 1 shared A. Wollman· 1 shared B. G. Davis· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

D. Sherratt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

L. P. Deimel, L. Moynie, G. Sun, V. Lewis, A. Turner, C. J. Buchanan, S. A. Burnap, C. M. Kobras, M. Stracy, W. B. Struwe, A. J. Baldwin, J. Naismith, B. G. Davis, Q. J. Sattentau

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

bioRxiv · Nov 2, 2023 · PreprintImmunology

RNA polymerase redistribution and increased gene dosage support growth in E. coli strains with a minimal number of ribosomal RNA operons

J. Fan, H. El Sayyed, O. J. Pambos, M. Stracy, J. Kyropoulos, A. N. Kapanidis

The paper investigates RNAP redistribution and increased gene dosage in E. coli with reduced rrn operons, showing RNAP clusters form near remaining rrn operons and growth defects are minimized.

bioRxiv · Feb 10, 2022 · PreprintMicrobiology

Competitive binding of MatP and topoisomerase IV to the MukB dimerization hinge

G. Fisher, J. R. Bolla, K. Rajasekar, j. makela, r. baker, m. zhou, j. prince, M. Stracy, C. V. Robinson, L. K. Arciszewska, D. Sherratt

The paper shows MatP and topoisomerase IV ParC compete for binding to the MukB dimerization hinge, with matS binding displacing MatP from the hinge.

bioRxiv · Mar 3, 2021 · PreprintBiochemistry

Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins

M. Stracy, J. schweizer, D. Sherratt, A. kapanidis, S. Uphoff, C. Lesterlin

This study shows that bacterial DNA-binding proteins spend most of their search time bound to DNA, with frequent short-lived interactions slowing their movement through the nucleoid.

bioRxiv · Aug 13, 2020Cell Biology

Single-molecule imaging of DNA gyrase activity in living Escherichia coli

M. Stracy, A. Wollman, E. Kaja, J. Gapinski, J.-E. Lee, V. Leek, S. McKie, L. Mitchenall, A. Maxwell, D. Sherratt, M. Leake, P. Zawadzki

This study uses single-molecule imaging to analyze DNA gyrase activity in live E. coli, showing gyrase dynamics and supercoil regulation during replication.

bioRxiv · Nov 1, 2018Biophysics