C. Sala

Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae

This study isolates human monoclonal antibodies against hypervirulent, pandrug-resistant Klebsiella pneumoniae and identifies capsule-specific antibodies as protective against bloodstream infection.

Human monoclonal antibodies reveal subdominant gonococcal and meningococcal cross-protective antigens

The paper identifies human monoclonal antibodies that recognize key antigens, PorB and LOS, providing cross-protection against gonococcal and meningococcal infections.

The Minimal Dataset for Cancer of the 1+Million Genomes Initiative

The paper develops a standardized data model for cancer genomics to enable interoperable data sharing across countries.

Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in Onco-Hematology

This paper applies Hierarchical Dirichlet Mixture Models to binary genomic data in AML to improve patient stratification and clustering through statistical refinements.

High-throughput bactericidal assays for monoclonal antibody screening against antimicrobial resistant Neisseria gonorrhoeae

This study develops high-throughput bactericidal assays to screen monoclonal antibodies against antimicrobial-resistant Neisseria gonorrhoeae, identifying potent antibodies validated by conventional methods.

mRNA vaccines and hybrid immunity use different B cell germlines to neutralize Omicron BA.4 and BA.5

The paper compares neutralizing antibodies against Omicron BA.4 and BA.5 from mRNA-vaccinated individuals and those with hybrid immunity, finding differences in epitope targeting and B cell germlines used.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody response

This study examines how a third mRNA vaccine dose enhances neutralizing antibody responses against SARS-CoV-2 variants by expanding specific B cell germlines and altering the antibody repertoire.

Hybrid immunity improves B cell frequency, antibody potency and breadth against SARS-CoV-2 and variants of concern

This study compares B cell responses in naive and convalescent individuals after SARS-CoV-2 vaccination, showing convalescents have higher frequency and broader neutralizing antibody responses against variants.

Discovering footprints of evolutionary chromatin response to transposons activity: merging biophysics with bioinformatics

The paper models LINEs activity as an ecosystem to infer evolutionary chromatin responses in mammals and primates, finding contrasting patterns in murine and primate lineages.

Extremely potent human monoclonal antibodies from convalescent Covid-19 patients

The paper isolates extremely potent human monoclonal antibodies from convalescent Covid-19 patients, effective against SARS-CoV-2 at low concentrations.

FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis

This study identifies FasR as a regulator of lipid metabolism in Mycobacterium tuberculosis, showing its essential role in virulence and immune evasion.

Identification of neutralizing human monoclonal antibodies from Italian Covid-19 convalescent patients

The paper isolates neutralizing human monoclonal antibodies from Covid-19 convalescent patients for therapeutic and prophylactic interventions.

Polarly localized EccE1is required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis

This study identifies EccE1 as a critical membrane protein required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis, with deletion of eccE1 reducing levels of other ESX-1 components and attenuating bacterial virulence.