Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering
P. Antoniou, L. Dacquay, N. Selfjord, K. Madeyski-Bengtson, A.-L. Loyd, E. Gordon, G. Thom, P.-P. Hsieh, S. Wimberger, S. Svikovic, M. Firth, N. Akrap, M. Maresca, M. Peterka
This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.
bioRxiv · Feb 1, 2024 · PreprintBioengineering