J. Edwards

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.

WNT Signalling Promotes NF-κB Activation and Drug Resistance in KRAS-Mutant Colorectal Cancer

This study shows that WNT signaling enhances NF-κB activation and drug resistance in KRAS-mutant colorectal cancer, suggesting a therapeutic strategy targeting WNT and MEK pathways.

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

Climate, host and geography shape insect and fungal communities of trees

This study identifies climate, host-related, and geographic factors shaping insect and fungal communities on trees, showing climate change could impact these communities through host range shifts and human-mediated transport.

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

This study uses spatial transcriptomics to identify prognostic immune and stromal subgroups in colorectal cancer liver metastases, revealing distinct transcriptomic programs associated with survival outcomes.

Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

Heritability and host genomic determinants of switchgrass root-associated microbiota in field sites spanning its natural range.

This study examines how host genetics and environmental factors shape root microbiota in switchgrass across its native range, finding heritable variation and local microbial recruitment.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

Microbiomes attached to fresh perennial ryegrass- are temporally resilient and adapt to changing ecological niches

This study investigates temporal ecological interactions at the fresh perennial ryegrass-biofilm interface in the rumen using metatranscriptomic profiling, identifying distinct sub-microbiomes and their functional roles.

Drought duration determines the recovery dynamics of rice root microbiomes

This study shows that drought duration affects the recovery of rice root microbiomes, with prolonged drought reducing resilience and altering microbial community dynamics.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

Selection-driven tumor evolution involving non-cell growth promotion leads to patterns of clonal expansion consistent with neutrality interpretation

This study uses agent-based modeling to show that tumor evolution driven by space acquisition and proliferation can produce clonal patterns resembling neutral evolution.

Physiotherapist and Podiatrist Independent Prescribing in the United Kingdom: A quasi experimental study

This study compares patient outcomes between physiotherapist and podiatrist independent prescribers and non-prescribers, finding similar quality of life and satisfaction but higher resource use for prescribers.

DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress in triple-negative breast cancer

This study identifies DYRK2 as a kinase that phosphorylates HSF1, enhancing its activity and promoting resistance to proteotoxic stress in TNBC, with implications for therapeutic targeting.

Rapid and dynamic nucleic acid hybridization enables enzymatic oligonucleotide synthesis by cyclic reversible termination

This paper demonstrates an enzymatic method for synthesizing oligonucleotides using cyclic reversible termination, achieving high efficiency and eliminating hazardous chemicals.

Compositional shifts in the root microbiota track the life-cycle of field-grown rice plants

This study tracks root microbiota changes in field-grown rice over its life cycle, showing dynamic shifts during the vegetative phase and correlations with developmental stages rather than age alone.

The rumen microbiome: an underexplored resource for novel antimicrobial discovery

The paper identifies novel antimicrobial peptides from the rumen microbiome and demonstrates their efficacy against MRSA in vitro and in a mouse model.