Author

M. Topper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Angelin· 1 shared A. Borczuk· 1 shared A. Chadburn· 1 shared A. Olali· 1 shared B. Agan· 1 shared C. L. Dalgard· 1 shared C. Lim· 1 shared C. Meydan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Angelin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

J. W. Guarnieri, M. Topper, K. Beigel, J. A. Haltoom, A. Chadburn, J. Frere, J. An, H. Cope, A. Borczuk, S. Sinha, C. Lim, J. Kim, J. Park, C. Meydan, J. Foox, , K Clark

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

bioRxiv · Oct 8, 2023 · PreprintImmunology

Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using In vitro Platform for Improving Insulin Therapy

S. Thoduvayil, J. S. Weerakkody, M. Topper, M. Bera, J. Coleman, X. Li, M. Mariappan, S. Ramakrishnan

The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.

bioRxiv · Apr 3, 2023Cell Biology

Aging interacts with tumor biology to produce major changes in the immune tumor microenvironment

R. Erbe, Z. Wang, N. Zaidi, M. Topper, S. Baylin, E. Jaffee, H. Easwaran, E. J. Fertig

The paper examines how aging interacts with tumor biology to alter the immune tumor microenvironment, identifying age-specific immune cell changes and immune checkpoint gene expression patterns.

bioRxiv · Jun 8, 2020 · PreprintCancer Biology