Author

J. Coleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. E. Rothman· 4 shared S. Ramakrishnan· 3 shared A. A. Hakimi· 2 shared A. Panda· 2 shared C. Brown· 2 shared C.-H. Lee· 2 shared E. Reznik· 2 shared F. Pincet· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

J. E. Rothman

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Author profile →

10 papers

Recent·Most cited

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

C. Brown, S. Ghosh, R. McAllister, M. Kumar, G. Walker, E. Sun, T. Aman, A. Panda, S. Kumar, W. V. Li, J. Coleman, Y. Liu, J. E. Rothman, M. Bhattacharyya, K. Gupta

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

bioRxiv · Feb 10, 2024Biophysics

Urbanisation generates multiple trait syndromes for terrestrial taxa worldwide

A. K. Hahs, B. Fournier, M. F. J. Aronson, C. H. Nilon, A. Herrera-Montes, A. Salisbury, C. G. Threlfall, C. C. Rega-Brodsky, C. A. Lepczyk, F. A. La Sorte, I. MacGregor-Fors, J. S. MacIvor, K. Jung, M. R. Piana, N. S. G. Williams, , Mat

This study shows urbanisation causes taxon-specific trait changes in terrestrial species, with reproductive and dietary traits most affected, and identifies four general urban trait syndromes.

bioRxiv · May 24, 2023 · PreprintEcology

Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using In vitro Platform for Improving Insulin Therapy

S. Thoduvayil, J. S. Weerakkody, M. Topper, M. Bera, J. Coleman, X. Li, M. Mariappan, S. Ramakrishnan

The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.

bioRxiv · Apr 3, 2023Cell Biology

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

A. Panda, F. Giska, A. L. Duncan, A. J. Welch, C. Brown, R. McAllister, H. Parameswaran, J. N. D. Goder, J. Coleman, S. Ramakrishnan, F. Pincet, L. Guan, S. Krishnakumar, J. E. Rothman, K. Gupta

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

bioRxiv · Mar 12, 2023Biophysics

Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma

D. S. Tourigny, M. Zucker, M. Kim, P. Russo, J. Coleman, C.-H. Lee, M. I. Carlo, Y.-B. Chen, A. A. Hakimi, R. R. Kotecha, E. Reznik

This study characterizes the tumor microenvironment of renal medullary carcinoma using genomic, metabolic, and single-cell RNA-sequencing data, identifying key molecular features and potential therapeutic targets.

bioRxiv · Apr 28, 2022 · PreprintCancer Biology

Molecular Determinants of Complexin Clamping in Reconstituted Single-Vesicle Fusion

M. Bera, S. Ramakrishnan, J. Coleman, S. S. Krishnakumar, J. E. Rothman

The paper identifies molecular mechanisms by which Complexin clamps SNARE assembly in single-vesicle fusion, showing its role in delaying fusion and enhancing clamping through specific structural interactions.

bioRxiv · Jul 5, 2021Biophysics

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

A. Yoo, C. Tang, M. Zucker, K. Fitzgerald, P. M. Rappold, K. Weiss, B. Freeman, C.-H. Lee, N. Schultz, R. Motzer, P. Russo, J. Coleman, V. E. Reuter, Y.-B. Chen, M. I. Carlo, , E. Reznik

This study compares the genomic and metabolic features of SDH- and FH-deficient renal cell carcinomas, identifying distinct genetic and metabolic abnormalities.

bioRxiv · Jun 9, 2021Cancer Biology

Vesicle capture by discrete self-assembled clusters of membrane-bound Munc13

F. Li, V. K. Sundaram, A. T. Gatta, J. Coleman, S. Krishnakumar, F. Pincet, J. E. Rothman

This study shows that Munc13 forms self-assembled clusters which are necessary for vesicle capture, with cluster size and the C2C domain affecting efficiency.

bioRxiv · Aug 17, 2020 · PreprintBiochemistry

Structural insight into outer membrane asymmetry maintenance of Gram-negative bacteria by the phospholipid transporter MlaFEDB

X. Tang, S. Chang, W. Qiao, Q. Luo, Y. Chen, Z. Jia, J. Coleman, K. Zhang, T. Wang, Z. Zhang, C. Zhang, X. Zhu, X. Wei, C. Dong, X. Zhang, H. Dong

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

bioRxiv · Jun 4, 2020Biochemistry

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

J. Coleman, E. Gouaux

The paper reports x-ray structures of the human serotonin transporter bound to antidepressants, explaining drug binding and selectivity mechanisms.

bioRxiv · Oct 17, 2017Biophysics