Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using In vitro Platform for Improving Insulin Therapy
S. Thoduvayil, J. S. Weerakkody, M. Topper, M. Bera, J. Coleman, X. Li, M. Mariappan, S. Ramakrishnan
The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.
bioRxiv · Apr 3, 2023Cell Biology