Author

M. McLean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Hannah R. BridgesiD· 2 shared Serena Liu· 2 shared Valentin PeretroukhiniD· 2 shared A. Arthur· 1 shared Ali PunjaniiD· 1 shared Amit SingeriD· 1 shared Carlos Óscar S. SorzanoiD· 1 shared Christina Wang· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

Hannah R. BridgesORCID

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Author profile →

3 papers

Recent·Most cited

End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC

CryoSPARC Team, Kelly Barber, Hannah R. Bridges, Suhail Dawood, Katherine Elder, Nick Frasser, Fiona Hu, Serena Liu, M. McLean, Ryan Narine, Telisha Ng, Valentin Peretroukhin, Ali Punjani, Harris Snyder, Kye Stachowski, , Nicholas Wong

This paper automates repeat-target cryo-EM structure determination in CryoSPARC, achieving high-resolution results for 21 GPCR datasets with minimal human intervention.

bioRxiv · Oct 17, 2025 · PreprintBiophysics

The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge

Miro A. Astore, Geoffrey Woollard, David Silva-Sánchez, Wenda Zhou, Mykhailo Kopylov, Khanh Dao Duc, Roy R. Lederman, Yilai Li, Yi Zhou, Jing Yuan, Fei Ye, Quanquan Gu, Rémi Vuillemot, Slavica Jonić, Lan Dang, , Sonya M. Hanson

The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.

bioRxiv · Jul 18, 2025 · PreprintBiophysics

Stromal fibroblast activation and inflammation in frozen shoulder

M. Akbar, M. McLean, E. Garcia-Melchor, L. A. Crowe, P. McMillan, U. G. Fazzi, D. Martin, A. Arthur, J. H. Reilly, I. B. McInnes, N. L. Millar

This study investigates stromal fibroblast activation and inflammation in frozen shoulder, finding increased expression of activation markers and inflammatory cytokines in diseased tissue.

bioRxiv · Oct 26, 2018 · PreprintImmunology