M. Mills

Characterization of human XPD helicase activity with Single Molecule Magnetic Tweezers

This study measures the DNA unwinding and translocation activities of human XPD helicase using magnetic tweezers, revealing it is a partially active enzyme with slow unwinding rates and sequence-dependent behavior.

MmCMS: Mouse models' Consensus Molecular Subtypes of colorectal cancer

The paper develops three methods to classify mouse colorectal cancer models into human CMS subtypes, finding that pathway-level classifiers outperform gene-level ones for accurate subtype identification.

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion

This study uses Nanopore Tweezers to measure RecQ helicase conformational changes, revealing an asymmetric energy landscape that allows it to maintain speed against opposing forces.

Echoes of the late Pleistocene in a novel trophic cascade between cougars and feral donkeys

The paper documents a trophic cascade where cougar predation on feral donkeys alters donkey behavior, reducing their impact on desert wetlands and increasing biodiversity.

Disconnects in global discourses - the unintended consequences of marine mammal protection on small-scale fishers

This study examines the conflict between marine mammal conservation and small-scale fisheries in Peru and Chile, finding that fishers perceive increased pinniped interactions and call for culls rather than compensation.

Using a residency index to estimate the economic value of saltmarsh provisioning services for commercially important fish species

This study estimates the economic value of saltmarsh habitats for UK commercial fisheries using a residency index that incorporates species life histories and habitat use.

Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage

This study shows that wound-induced polyploidization in Drosophila epithelium, driven by Myc, supports tissue repair by blocking mitosis and avoiding DNA damage.

Direct Observation of Topoisomerase IA Gate Dynamics

This study directly observes the gate dynamics of E. coli type IA topoisomerases I and III using a single-molecule assay, revealing gate opening and force resistance.